Commercial Production of Lactoferrin, a Multifunctional Iron-binding Glycoprotein
نویسندگان
چکیده
منابع مشابه
Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis
Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses. HLf and bovine Lf (bLf), possessing high sequence homology and identical functions, inhibit bacterial growth and biofilm dependently from iron binding ability while, independently, bacterial adhesion to and the entry into cells. In inf...
متن کاملReview study on lactoferrin: A multifunctional protein
Lactoferrin is a glycoprotein of 703 amino acids originally isolated from milk. Lactoferrin exists in body fluids and can be found in the form of free iron, monoferric and diferic form. Scientist also found lactoferrin in the secretions of mammal’s pancreas, and in secondary neutrophil granules. Lactoferrin has wide range of functions which may range from binding of Lactoferrin with iron, in co...
متن کاملInhibition of lipid peroxidation by the iron-binding protein lactoferrin.
Lactoferrin containing physiological amounts of iron is an inhibitor of lipid peroxidation induced by iron(III) salts and ascorbic acid. It might therefore help to protect neutrophils, inflammatory foci and secretions from metal-ion-dependent oxidative damage.
متن کامل[Lactoferrin - a glycoprotein of great therapeutic potentials].
Lactoferrin is an iron-binding glycoprotein, which is present in most biological fluids with particularly high levels in colostrum and in mammalian milk. Bovine lactoferrin is more than 70% homologous with human lactoferrin. Most of the clinical trials have used bovine lactoferrin for supplementation. This review summarizes the recent advances in explaining the mechanisms, which are responsible...
متن کاملMultifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions.
Lactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity reports on lactoferrin identified its significance in host defense against infection and extreme inf...
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ژورنال
عنوان ژورنال: Biotechnology and Genetic Engineering Reviews
سال: 1997
ISSN: 0264-8725,2046-5556
DOI: 10.1080/02648725.1997.10647946